Why is there little to no medical progress in these 2 areas?

In 1942 there was renal hemodialysis which could save the lives of patients with endstage renal disease but only at the cost of utterly destroying their quality of life. The same situation obtains today. In 1922 there was insulin to treat diabetes, but the treatment dosing was onerous and dangerous, and no amount of precision obtainable could prevent neurological and vascular complications and premature death. The situation is still the same today.